Anticarcinogenic factors in plant foods: a new class of nutrients?

INTRODUCTION . . , 175 MECHANISMS OF CARCINOGENESIS . . 176 BLOCKING AGENTS . . 178 PHASE I METABOLISM ACTIVATION BY MONOOXYGENASES . . 178 Free radical mediated damage . . 180 Alternative route to phase I metabolism quinone reductase (QR) . . 181 C O N J U G A T I O N BY PHASE I1 ENZYMES . . 183 INDIRECT EFFECTS V I A ENTERIC BACTERIAL METABOLISM , . 184 INDUCERS OF D N A REPAIR . . 185 SUPPRESSING AGENTS . . 186 INHIBITORS OF CELL PROLIFERATION . . 186 Modijication of intracellular signalling . . . 187 Inhibition of oncogene expression . . . 188 Polyamine metabolism . . 188 Oestrogen metabolism . . 189 DIRECT A C T I N G MODULATORS OF CELL D A M A G E . . . 190 Suppression of free radical production . . . 190 Selective cytotoxins . . 191 I N D U C E R S OF C E L L U L A R DIFFERENTIATION . . 191 ANTIMETASTATIC AGENTS . . 192 IMMUNOMODULATION . . 192 A NEW CLASS OF NUTRIENTS?. . . 192 REFERENCES . . . 194